Neuroanatomy, Pain and Psychopathology
Team leaders : Michel Barrot, Ipek Yalcin
Our researches concern chronic pain, with a focus on neuropathic pain that arises as a consequence of a lesion or disease of the nervous system. We are studying its treatments, in particular by antidepressant drugs, as well as its affective and anxio-depressive consequences. We also have strong expertise in neuroanatomy, and are studying brain circuits underlying the various components of pain, of emotions and of the control of aminergic systems.
Team projects
- Neuropathic pain treatments
Michel Barrot - Chronic pain and mood disorder comorbidity
Ipek Yalcin - Dopaminergic systems implications in mood disorders associated with chronic pain
Jennifer Kaufling - Neuroanatomy of brain circuits
Pierre Veinante - The tail of the ventral tegmental area, a new control center of the dopaminergic systems
Michel Barrot & Jennifer Kaufling - Epigenomics of opioid addiction
Pierre-Eric Lutz - Peripheral biomarkers of psychiatric disorders
Pierre-Eric Lutz
Members
Researchers / Professors / Assistant Professors
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Michel Barrot (Senior researcher) |
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Pierre-Eric Lutz (Researcher) |
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Jennifer Kaufling (Researcher) |
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Pierre Veinante (Professor) |
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Ipek Yalcin (Senior researcher) |
Postdoctoral fellow / Ph.D. student
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Victor Mathis (Post-doc) |
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Camille Falconnier (PhD student) |
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Alba Caparros-Roissard (PhD student) |
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Marion Schott (PhD student) |
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Pierre-Alexis Derrien (PhD student) |
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Margot Diringer (PhD student) |
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Mithil Gaikwad (PhD student) |
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Hanus Slavik (Post-doc) |
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Vandana Shree Srinivasan (PhD student) |
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Susana Lima (PhD student) |
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Benjamin Muller (PhD student) |
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Marilou Lentschat (PhD student) |
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Yahia Hadj-Arab (PhD student) |
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Esther Colantonio (PhD student) |
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Yechao Han (PhD student) |
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Ariadni Bella (PhD student) |
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Enora Langlois (PhD student) |
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Henrico-Pio Basile (PhD student) |
Selected publications
Kremer M, Yalcin I, Goumon Y, Wurtz X, Nexon L, Daniel D, Megat S, Ceredig RA, Ernst C, Turecki G, Chavant V, Theroux JF, Lacaud A, Joganah LE, Lelievre V, Massotte D, Lutz PE, Gilsbach R, Salvat E, Barrot M (2018) A dual noradrenergic mechanism for the relief of neuropathic allodynia by the antidepressant drugs duloxetine and amitriptyline. Journal of Neuroscience 38:9934-9954
Sellmeijer J, Mathis V, Hugel S, Li XH, Song Q, Chen QY, Barthas F, Lutz PE, Karatas M, Luthi A, Veinante P, Aertsen A, Barrot M, Zhuo M, Yalcin I (2018) Hyperactivity of anterior cingulate cortex areas 24a/24b drives chronic pain-induced depression. Journal of Neuroscience 38:3102-3115
Lutz PE, Chay MA, Pacis A, Chen GG, Aouabed Z, Maffioletti E, Theroux JF, Grenier JC, Yang J, Aguirre M, Ernst C, Redensek R, van Kempen L, Yalcin I, Kwan T, Mechawar N, Turecki G (2021) Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation. Nature Communications 12(1):1132
