The French National Centre for Scientific Research


Intracellular membrane trafficking in the nervous and neuroendocrine systems


Team leaders : Stéphane Gasman & Nicolas Vitale



Functioning of the nervous and neuroendocrine systems is based on the release of informative molecules thanks to various tightly regulated membrane trafficking processes (exocytosis, endocytosis, vesicular transport). Our research aims at deciphering the molecular mechanisms regulating these trafficking events and at unravelling their dysfunction associated with important pathologies (mental retardation, neurodegenerative diseases, neuroendocrine cancers, obesity…). Using neurons, neuroendocrine cells and ependymal cells, we are particularly studying the mechanisms by which different lipids and proteins control the life cycle of vesicles, starting from biogenesis to membrane fusion through their intracellular transport.


Team projects



Members

Researchers / Professors / Assistant Professors

Marie-France Bader Marie-France Bader
(Senior researcher)
 
Sylvette Chasserot-Golaz Sylvette Chasserot-Golaz
(Researcher)
 
Stéphane Gasman Stéphane Gasman
(Senior researcher)
 
Stéphane Ory Stéphane Ory
(Researcher)
 
Petra Tóth Petra Tóth
(Associate professor)
 
Nicolas Vitale Nicolas Vitale
(Senior researcher)
 

Postdoctoral fellow / Ph.D. student

Maria Caputo Margherita Caputo
(Ph.D. Student)
 
Laura Streit Laura Streit
(Ph.D. Student)
 
Michael Okafor Michael Okafor
(Ph.D. Student)
 
Alexander Wolf Alexander Wolf
(Ph.D. Student)
 
Emeline Tanguy Emeline Tanguy
(Postdoctoral fellow)
 
Qili Wang Qili Wang
(Postdoctoral fellow)
 

Engineers / Technicians

Claudine Boissier Claudine Boissier
 
Anne-Marie Haeberlé Anne-Marie Haeberlé
 
Jason Ecard Jason Ecard
 
Sebahat Ozkan Sebahat Ozkan
 



Selected publications

Duquenne M, Folgueira C, Bourrouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, Martinez-Corral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, Ory S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S, Dam J & Prévot V (2021) Leptin enters the brain through a LepR:EGFR shuttle in tanycytes to regulate peripheral lipogenesis and pancreatic beta-cell function. Nature Metabolism Aug;3(8):1071-1090.

Tanguy E, Coste de Bagneaux P, Kassas N, Ammar MR, Wang Q, Haeberle AM, Raherindratsara J, Fouillen L, Renard PY, Montero-Hadjadje M, Chasserot-Golaz S, Ory S, Gasman S, Bader MF, Vitale N (2020) Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells. Cell Rep 32:108026.

Gubar O, Croise P, Kropyvko S, Gryaznova T, Toth P, Blangy A, Vitale N, Rynditch A, Gasman S, Ory S (2020) The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways. J Cell Sci Aug 27;133(16):jcs234104.

Gabel M, Delavoie F, Royer C, Tahouly T, Gasman S, Bader MF, Vitale N, Chasserot-Golaz S (2019) Phosphorylation cycling of Annexin A2 Tyr23 is critical for calcium-regulated exocytosis in neuroendocrine cells. Biochim Biophys Acta (Mol Cell Res) 1866:1207-1217.

Chopard C, Tong PBV, Toth P, Schatz M, Yezid H, Debaisieux S, Mettling C, Gross A, Pugniere M, Tu A, Strub JM, Mesnard JM, Vitale N, Beaumelle B (2018) Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells. Nat Commun 9:2251.

Moog S, Houy S, Chevalier E, Ory S, Weryha G, Rame M, Klein M, Brunaud L, Gasman S, Cuny T (2018) 18F-FDOPA PET/CT Uptake Parameters Correlate with Catecholamine Secretion in Human Pheochromocytomas. Neuroendocrinology 107:228-236.

 


 
The French National Centre for Scientific Research