The French National Centre for Scientific Research


Neuroanatomy, Pain and Psychopathology

Team leaders : Michel Barrot, Ipek Yalcin



Our researches concern chronic pain, with a focus on neuropathic pain that arises as a consequence of a lesion or disease of the nervous system. We are studying its treatments, in particular by antidepressant drugs, as well as its affective and anxio-depressive consequences. We also have strong expertise in neuroanatomy, and are studying brain circuits underlying the various components of pain, of emotions and of the control of aminergic systems.



Team projects



Members

Researchers / Professors / Assistant Professors

Michel Barrot
(Senior researcher)
 
Pierre-Eric Lutz
(Researcher)
 
Jennifer Kaufling
(Researcher)
Email
 
Dominique Massotte
(Senior researcher)
 
Eric Salvat
(HP)
 
Pierre Veinante
(Professor)
 
Ipek Yalcin
(Senior researcher)
 
Marie-José Freund-Mercier
(Professor)
 
André Muller
(Professor)
 

Postdoctoral fellow / Ph.D. student

Camille Falconnier
(PhD student)
 
Marion Gaborit
(PhD student)
 
Sarah Journée
(PhD student)
 
Anil Joshi
(PhD student)
 
Marion Schott
(PhD student)
 
Pierre-Alexis Derrien
(PhD student)
 
Léa Becker
(PhD student)
 

Engineers / Technicians

Pierre Hener
 
Robin Waegaert
 
Alba Caparros-Roissard
 


Selected publications

Kremer M, Yalcin I, Goumon Y, Wurtz X, Nexon L, Daniel D, Megat S, Ceredig RA, Ernst C, Turecki G, Chavant V, Theroux JF, Lacaud A, Joganah LE, Lelievre V, Massotte D, Lutz PE, Gilsbach R, Salvat E, Barrot M (2018) A dual noradrenergic mechanism for the relief of neuropathic allodynia by the antidepressant drugs duloxetine and amitriptyline. Journal of Neuroscience 38:9934-9954

Sellmeijer J, Mathis V, Hugel S, Li XH, Song Q, Chen QY, Barthas F, Lutz PE, Karatas M, Luthi A, Veinante P, Aertsen A, Barrot M, Zhuo M, Yalcin I (2018) Hyperactivity of anterior cingulate cortex areas 24a/24b drives chronic pain-induced depression. Journal of Neuroscience 38:3102-3115

Lutz PE, Chay MA, Pacis A, Chen GG, Aouabed Z, Maffioletti E, Theroux JF, Grenier JC, Yang J, Aguirre M, Ernst C, Redensek R, van Kempen L, Yalcin I, Kwan T, Mechawar N, Turecki G (2021) Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation. Nature Communications 12(1):1132

 


 
The French National Centre for Scientific Research