Team leader : Rémy Schlichter and Dominique Massotte
The dorsal horn of the spinal cord is involved in the integration of nociceptive messages from peripheral primary afferent nociceptors. When transferred to supraspinal centers this information can lead to the perception of pain. We aim at understanding how nociceptive information is processed and modulated by neuronal and glial networks of the dorsal horn, and how plastic changes underlie the development of chronic pain states.
To reach this goal, we are studying native neuronal networks (spinal cord slices) or reconstituted networks (cultures of neurons and glial cells from the dorsal horn or from the dorsal root ganglia), as well as the interactions between neurons and glia, using electrophysiological methods and fluorescent probes imaging.
Team projects
- Nociceptive networks in the valproate mice model of autism
Jean-Louis Bossu - Sex, analgesic drugs and Metabolism
Yannick Goumon - Activity-dependent plasticity of inhibitory synapses in the dorsal horn
Sylvain Hugel - Modulation and plasticity of spinal inhibition
Perrine Inquimbert - Functional Dynamics of Opioid Receptors
Dominique Massotte - Calcium signalling and information processing in dorsal horn glial cells
Rémy Schlichter
Members
Jean-Louis Bossu
(DR2 CNRS)
Perrine Inquimbert
(MC Unistra)
Dominique Massotte
(DR2 CNRS)
Rémy Schlichter
(PR Unistra)
Karim Berkati
Marion Gaborit
Volodya Hovhannisyan
Robin Kuster
Lucien Ruelle-Le Glaunec
Louise Vial
Patrick Wolf
Virginie Andry
(IE CNRS)
Chantal Fitterer
(AI CNRS)
Catherine Moreau
(AI Unistra)
Benjamin Léonardon
(PhD student)
Lou Cathenaut
(PhD student)
Varen Eersapah
(PhD student)
Florian Gabel
(PhD student)
Selected publications
Roux S, Lohof A, Ben-Ari Y, Poulain B, Bossu JL. Maturation of GABAergic Transmission in Cerebellar Purkinje Cells Is Sex Dependent and Altered in the Valproate Model of Autism. Front Cell Neurosci.2018 Jul 30;12:232.
Inquimbert P, Moll M, Latremoliere A, Tong CK, Whang J, Sheehan GF, Smith BM, Korb E, Athié MCP, Babaniyi O, Ghasemlou N, Yanagawa Y, Allis CD, Hof PR, Scholz J. NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury. Cell Rep. 2018 May 29;23(9):2678-2689.
Weinsanto I, Laux-Biehlmann A, Mouheiche J, Maduna T, Delalande F, Chavant V, Gabel F, Darbon P, Charlet A, Poisbeau P, Lamshöft M, Van Dorsselaer A, Cianferani S, Parat MO, Goumon Y. Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice British Journal of Pharmacology. 2018 Jul 11;175:3844-3856.
Cordero-Erausquin M, Inquimbert P, Schlichter R, Hugel S. Neuronal networks and nociceptive processing in the dorsal horn of the spinal cord. Neuroscience. 2016 Dec 3;338:230-247.
