Team leader : Rémy Schlichter
The dorsal horn of the spinal cord is involved in the integration of nociceptive messages from peripheral primary afferent nociceptors. When transferred to supraspinal centers this information can lead to the perception of pain. We aim at understanding how nociceptive information is processed and modulated by neuronal and glial networks of the dorsal horn, and how plastic changes underlie the development of chronic pain states.
To reach this goal, we are studying native neuronal networks (spinal cord slices) or reconstituted networks (cultures of neurons and glial cells from the dorsal horn or from the dorsal root ganglia), as well as the interactions between neurons and glia, using electrophysiological methods and fluorescent probes imaging.
- Modulation and plasticity of spinal inhibition
- Activity-dependent plasticity of inhibitory synapses in the dorsal horn
- Calcium signalling and information processing in dorsal horn glial cells
- Nociceptive networks in the valproate mice model of autism
- Sex, analgesic drugs and Metabolism
Lucien Ruelle-Le Glaunec
Roux S, Lohof A, Ben-Ari Y, Poulain B, Bossu JL. Maturation of GABAergic Transmission in Cerebellar Purkinje Cells Is Sex Dependent and Altered in the Valproate Model of Autism. Front Cell Neurosci.2018 Jul 30;12:232.
Inquimbert P, Moll M, Latremoliere A, Tong CK, Whang J, Sheehan GF, Smith BM, Korb E, Athié MCP, Babaniyi O, Ghasemlou N, Yanagawa Y, Allis CD, Hof PR, Scholz J. NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury. Cell Rep. 2018 May 29;23(9):2678-2689.
Weinsanto I, Laux-Biehlmann A, Mouheiche J, Maduna T, Delalande F, Chavant V, Gabel F, Darbon P, Charlet A, Poisbeau P, Lamshöft M, Van Dorsselaer A, Cianferani S, Parat MO, Goumon Y. Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice British Journal of Pharmacology. 2018 Jul 11;175:3844-3856.
Cordero-Erausquin M, Inquimbert P, Schlichter R, Hugel S. Neuronal networks and nociceptive processing in the dorsal horn of the spinal cord. Neuroscience. 2016 Dec 3;338:230-247.