Team leader: Etienne Challet
Our team investigates functioning of the cerebral clocks and their resetting by feeding, metabolic and arousing signals with an integrative approach combining molecular biology and comparative physiology. Our main goal is to identify the pathways through which the brain clocks control the rhythmicity of physiological processes, such as the daily feeding/fasting cycle and meal anticipation, and how they are regulated by feeding and arousing cues.
- Interactions between cerebral clocks and food intake: temporal and metabolic aspects.
Patrick VUILLEZ & Etienne CHALLET
- Functional links between circadian system and structures regulating wakefulness and energy metabolism.
Sylvie RAISON & Etienne CHALLET
(Unistra assistant engineer)
Challet E (2019). The circadian regulation of food intake. Nat Rev Endocrinol 15: 393-405.
Klosen P, Lapmanee S, Schuster C, Guardiola B, Hicks D, Pevet P, Felder-Schmittbuhl MP (2019). MT1 and MT2 melatonin receptors are expressed in non-overlapping neuronal populations. J Pineal Res 67: e12575.
Sen S, Dumont S, Sage-Ciocca D, Reibel S, de Goede P, Kalsbeek A, Challet E (2018). Expression of the clock gene Rev-erba in the brain controls the circadian organization of food intake and locomotor activity, but not daily variations of energy metabolism. J Neuroendocrinol 30: e12557.
Sen S, Raingard H, Dumont S, Kalsbeek A, Vuillez P, Challet E (2017). Ultradian feeding in mice not only affects the peripheral clock in the liver, but also the master clock in the brain. Chronobiol Int 34: 17-36.
Jha PK, Bouaouda H, Gourmelen S, Dumont S, Fuchs F, Goumon Y, Bourgin P, Kalsbeek A, Challet E (2017).
Sleep deprivation and caffeine treatment potentiate photic resetting of the master circadian clock in a diurnal rodent. J Neurosci 37: 4343-4358.
Delezie J, Dumont S, Sandu C, Reibel S, Pevet P, Challet E (2016) Rev-erba in the brain is essential for circadian food entrainment. Sci Rep 6: 29386.
Grosbellet E, Zahn S, Arrive M, Dumont S, Gourmelen S, Pevet P, Challet E*, Criscuolo F* (2015). Circadian desynchronization triggers premature cellular aging in a diurnal rodent. FASEB J 29:4794-4803.