Team leaders: Marie-Paule Felder-Schmittbuhl & Frank Pfrieger
Our team is interested in molecular and cellular mechanisms regulating retinal physiopathology and its connections with the brain. Using a wide range of models and methods, we study how cell-cell interactions control retinal function, development, aging and vulnerability to diseases, and how their integration conveys information to the central circadian clock and to other brain regions regulating behaviour.
- Functional organisation of retinal clock(s)
- Retinal disease, central vision loss and pathophysiology of cone photoreceptors
- Non visual effects of blue light on the retina and the brain
- Light-entrained brain circadian clocks: regulation of motivated behaviors
- Cholesterol metabolism in retinal health and disease
Felder-Schmittbuhl MP, Buhr ED, Dkhissi-Benyahya O, Hicks D, Peirson SN, Ribelayga CP, Sandu C, Spessert R, Tosini G. Ocular Clocks: Adapting Mechanisms for Eye Functions and Health. Invest Ophthalmol Vis Sci. (2018) 59:4856-4870. doi: 10.1167/iovs.18-24957.
Laurent V, Sengupta A., Sánchez-Bretaño A., Hicks D., Tosini G. Melatonin Signaling Affects the Timing in the Daily Rhythm of Phagocytic Activity by the Retinal Pigment Epithelium. Exp. Eye Res.; Dec; 165:90-95.
Salaberry NL, Hamm H, Felder-Schmittbuhl MP, Mendoza J. A suprachiasmatic-independent circadian clock(s) in the habenula is affected by Per gene mutations and housing light conditions in mice. Brain Struct Funct. 2019 Jan;224(1):19-31. doi: 10.1007/s00429-018-1756-4.
Verra DM, Sajdak BS, Merriman DK, Hicks D. Diurnal rodents as pertinent animal models of human retinal physiology and pathology. Prog Retin Eye Res. 2019 Sep 6:100776. doi:10.1016/j.preteyeres.2019.100776.