Team leaders: Marie-Paule Felder-Schmittbuhl & Frank Pfrieger
Our team is interested in molecular and cellular mechanisms regulating retinal physiopathology and its connections with the brain. Using a wide range of models and methods, we study how cell-cell interactions control retinal function, development, aging and vulnerability to diseases, and how their integration conveys information to the central circadian clock and to other brain regions regulating behaviour.
Team projects
- Functional organisation of retinal clock(s)
Marie-Paule Felder-Schmittbuhl - Retinal disease, central vision loss and pathophysiology of cone photoreceptors
David Hicks - Non visual effects of blue light on the retina and the brain
Virginie Laurent-Gydé - Light-entrained brain circadian clocks: regulation of motivated behaviors
Jorge Mendoza - Cholesterol metabolism in retinal health and disease
Frank Pfrieger
Members
Marie-Paule Felder-Schmittbuhl
(Senior researcher)
David Hicks
(Senior researcher)
Virginie Laurent-Gydé
(Associate professor)
Jorge Mendoza
(Senior researcher)
Viviane Pallage
(Researcher)
Frank Pfrieger
(Senior researcher)
Daniela Verra
Udita Bagchi
Noëmi Billon
Shumet Gegnaw
Bastien Leclercq
Nadia Mazzaro
Nemanja Milicevic
Fabiana Sassone
Guillaume Vanotti
Amélie Bathélémy
Cristina Sandu
Selected publications
Felder-Schmittbuhl MP, Buhr ED, Dkhissi-Benyahya O, Hicks D, Peirson SN, Ribelayga CP, Sandu C, Spessert R, Tosini G. Ocular Clocks: Adapting Mechanisms for Eye Functions and Health. Invest Ophthalmol Vis Sci. (2018) 59:4856-4870. doi: 10.1167/iovs.18-24957.
Laurent V, Sengupta A., Sánchez-Bretaño A., Hicks D., Tosini G. Melatonin Signaling Affects the Timing in the Daily Rhythm of Phagocytic Activity by the Retinal Pigment Epithelium. Exp. Eye Res.; Dec; 165:90-95.
Salaberry NL, Hamm H, Felder-Schmittbuhl MP, Mendoza J. A suprachiasmatic-independent circadian clock(s) in the habenula is affected by Per gene mutations and housing light conditions in mice. Brain Struct Funct. 2019 Jan;224(1):19-31. doi: 10.1007/s00429-018-1756-4.
Verra DM, Sajdak BS, Merriman DK, Hicks D. Diurnal rodents as pertinent animal models of human retinal physiology and pathology. Prog Retin Eye Res. 2019 Sep 6:100776. doi:10.1016/j.preteyeres.2019.100776.
