Intracellular membrane trafficking in the nervous and neuroendocrine systems


Team leaders : Stéphane Gasman & Nicolas Vitale



Functioning of the nervous and neuroendocrine systems is based on the release of informative molecules thanks to various tightly regulated membrane trafficking processes (exocytosis, endocytosis, vesicular transport). Our research aims at deciphering the molecular mechanisms regulating these trafficking events and at unravelling their dysfunction associated with important pathologies (mental retardation, neurodegenerative diseases, neuroendocrine cancers, obesity…). Using neurons, neuroendocrine cells and ependymal cells, we are particularly studying the mechanisms by which different lipids and proteins control the life cycle of vesicles, starting from biogenesis to membrane fusion through their intracellular transport.


Team projects



Members

Researchers / Professors / Assistant Professors


Marie-France Bader
(Inserm researcher)

Sylvette Chasserot-Golaz
(Inserm researcher)

Stéphane Gasman
(Inserm researcher)

Stéphane Ory
(CNRS researcher)

Petra Tóth
(Associate professor)

Nicolas Vitale
(Inserm researcher)

PhD students / Post-doc


Margherita Caputo
(Ph.D Student)

Marion Millet
(Ph.D Student)

Michael Okafor
(Ph.D Student)

Laura Streit
(Ph.D Student)

Emeline Tanguy
(Post-doc)

Qili Wang
(Ph.D Student)

Engineers / Technicians


Claudine Boissier
(AJT Unistra)

Anne-Marie Haeberlé
(IE HC CNRS)

Tamou Thahouly
(AI CNRS)

Sebahat Ozkan
(AI CNRS)

Audrey Groh
(IE CDD CNRS)



Selected publications

Chopard C, Tong PBV, Toth P, Schatz M, Yezid H, Debaisieux S, Mettling C, Gross A, Pugniere M, Tu A, Strub JM, Mesnard JM, Vitale N, Beaumelle B (2018) Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells. Nat Commun 9:2251.

Kassas N, Tanguy E, Thahouly T, Fouillen L, Heintz D, Chasserot-Golaz S, Bader MF, Grant NJ, Vitale N (2017) Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis. J Biol Chem 292:4266-4279.

Croise P, Houy S, Gand M, Lanoix J, Calco V, Toth P, Brunaud L, Lomazzi S, Paramithiotis E, Chelsky D, Ory S, Gasman S (2016) Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression. Endocr Relat Cancer 23:281-293.

Gabel M, Delavoie F, Demais V, Royer C, Bailly Y, Vitale N, Bader MF, Chasserot-Golaz S (2015) Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis. J Cell Biol 210:785-800.

Houy S, Estay-Ahumada C, Croise P, Calco V, Haeberle AM, Bailly Y, Billuart P, Vitale N, Bader MF, Ory S, Gasman S (2015) Oligophrenin-1 Connects Exocytotic Fusion to Compensatory Endocytosis in Neuroendocrine Cells. J Neurosci 35:11045-11055.