The French National Centre for Scientific Research

Intracellular membrane trafficking in the nervous and neuroendocrine systems

Team leaders : Stéphane Gasman & Nicolas Vitale

Functioning of the nervous and neuroendocrine systems is based on the release of informative molecules thanks to various tightly regulated membrane trafficking processes (exocytosis, endocytosis, vesicular transport). Our research aims at deciphering the molecular mechanisms regulating these trafficking events and at unravelling their dysfunction associated with important pathologies (mental retardation, neurodegenerative diseases, neuroendocrine cancers, obesity…). Using neurons, neuroendocrine cells and ependymal cells, we are particularly studying the mechanisms by which different lipids and proteins control the life cycle of vesicles, starting from biogenesis to membrane fusion through their intracellular transport.

Team projects


Researchers / Professors / Assistant Professors

Marie-France Bader Marie-France Bader
(Senior researcher)
Sylvette Chasserot-Golaz Sylvette Chasserot-Golaz
Stéphane Gasman Stéphane Gasman
(Senior researcher)
Stéphane Ory Stéphane Ory
Petra Tóth Petra Tóth
(Associate professor)
Nicolas Vitale Nicolas Vitale
(Senior researcher)

Postdoctoral fellow / Ph.D. student

Maria Caputo Margherita Caputo
(Ph.D. Student)
Laura Streit Laura Streit
(Ph.D. Student)
Michael Okafor Michael Okafor
(Ph.D. Student)
Alexander Wolf Alexander Wolf
(Ph.D. Student)
Emeline Tanguy Emeline Tanguy
(Postdoctoral fellow)

Engineers / Technicians

Claudine Boissier Claudine Boissier
Anne-Marie Haeberlé Anne-Marie Haeberlé
Tamou Thahouly Tamou Thahouly
Sebahat Ozkan Sebahat Ozkan

Selected publications

Tanguy E, Coste de Bagneaux P, Kassas N, Ammar MR, Wang Q, Haeberle AM, Raherindratsara J, Fouillen L, Renard PY, Montero-Hadjadje M, Chasserot-Golaz S, Ory S, Gasman S, Bader MF, Vitale N (2020) Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells. Cell Rep 32:108026.

Gubar O, Croise P, Kropyvko S, Gryaznova T, Toth P, Blangy A, Vitale N, Rynditch A, Gasman S, Ory S (2020) The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways. J Cell Sci 133(16).

Gabel M, Delavoie F, Royer C, Tahouly T, Gasman S, Bader MF, Vitale N, Chasserot-Golaz S (2019) Phosphorylation cycling of Annexin A2 Tyr23 is critical for calcium-regulated exocytosis in neuroendocrine cells. Biochim Biophys Acta (Mol Cell Res) 1866:1207-1217.

Chopard C, Tong PBV, Toth P, Schatz M, Yezid H, Debaisieux S, Mettling C, Gross A, Pugniere M, Tu A, Strub JM, Mesnard JM, Vitale N, Beaumelle B (2018) Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells. Nat Commun 9:2251.

Kassas N, Tanguy E, Thahouly T, Fouillen L, Heintz D, Chasserot-Golaz S, Bader MF, Grant NJ, Vitale N (2017) Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis. J Biol Chem 292:4266-4279.

Croise P, Houy S, Gand M, Lanoix J, Calco V, Toth P, Brunaud L, Lomazzi S, Paramithiotis E, Chelsky D, Ory S, Gasman S (2016) Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression. Endocr Relat Cancer 23:281-293.

Gabel M, Delavoie F, Demais V, Royer C, Bailly Y, Vitale N, Bader MF, Chasserot-Golaz S (2015) Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis. J Cell Biol 210:785-800.

Houy S, Estay-Ahumada C, Croise P, Calco V, Haeberle AM, Bailly Y, Billuart P, Vitale N, Bader MF, Ory S, Gasman S (2015) Oligophrenin-1 Connects Exocytotic Fusion to Compensatory Endocytosis in Neuroendocrine Cells. J Neurosci 35:11045-11055.


The French National Centre for Scientific Research