Oxytocinergic modulation of astrocytes-neurones networkds orchestrating emotional control
Project leader : Alexandre Charlet
Oxytocin is an evolutionarily ancient neuropeptide, found in species ranging from invertebrates to mammals, synthesized and released mainly from the paraventricular and supraoptic nucleus of the hypothalamus. Oxytocin has firmly grasped our attention over the last several years and its central release have been shown to orchestrate the modulation of cognition and emotion. We recently identified a small population of only thirty oxytocinergic neurons of particular interest in the control of pain (Eliava et al., Neuron, 2016), and that a small subpopulation of oxytocinergic neurons can form engrams able to modulate emotions such as fear (Hasan et al., Neuron, 2019). Finally, we just demonstrated how oxytocin is released to control social interactions (Tang et al., Nature Neuroscience, 2020). Since a few years, we are interested in the role of astrocytes in the oxytocinergic modulation of neuronal circuits underlying emotions, with a special focus in the central amygdala centrale (Wahis et al., Nature Neuroscience, 2021). Using ex vivo patch-clamp and calcium imaging combined with selective optogenetic manipulation of oxytocinergic neurons or local astrocytes, we currently examine how oxytocin can modulate the amygdala neuro-glia network involved in the emotional process of pain and anxiety.
Prof. Valery Grinevich, Mannheim, Germany.
Prof. Javier Stern group CNS mechanisms in cardiometabolic diseases, Georgia State University, USA.
Prof. Bice Chini group Neurobiology of oxytocin and vasopressin receptors, CNR Neuroscience Institute, Milan, Italy.
Dr. Nathalie Rouach group neuroglial interactions in cerebral physiopathology, Collège de France, Paris, France.