Nociceptive networks in the valproate mice model of autism
Project leader : Jean-Louis Bossu
Autism is a neurodevelopmental pathology characterized by a lack of communication and social interaction associated with repetitive behaviours and restricted interests. Autism Spectrum Disorders (ASD) reflect a dysfunction in the integration of sensory and particularly harmful information. The objective of our work is to characterize disruptions of harmful signal integration in the valproate mouse model of autism. We study changes in neural networks in the dorsal horn of the spinal cord that integratenociceptive messages from the periphery. To this end, we use a combination of experimental techniques such as electrophysiology, calcium imaging on spinal cord slices and behavioural tests to assess mechanical and thermal nociceptive sensitivity in this animal model of autism.
Lucien Ruelle-Le Glaunec