The French National Centre for Scientific Research


Nociceptive networks in the valproate mice model of autism


Project leader : Jean-Louis Bossu




Autism is a neurodevelopmental pathology characterized by a lack of communication and social interaction associated with repetitive behaviours and restricted interests. Autism Spectrum Disorders (ASD) reflect a dysfunction in the integration of sensory and particularly harmful information. The objective of our work is to characterize disruptions of harmful signal integration in the valproate mouse model of autism. We study changes in neural networks in the dorsal horn of the spinal cord that integratenociceptive messages from the periphery. To this end, we use a combination of experimental techniques such as electrophysiology, calcium imaging on spinal cord slices and behavioural tests to assess mechanical and thermal nociceptive sensitivity in this animal model of autism.


Members


Jean-Louis BOSSU

Lucien Ruelle-Le Glaunec

 


 
The French National Centre for Scientific Research