The French National Centre for Scientific Research

Functional organisation of retinal clock(s)

Project leader : Marie-Paule Felder-Schmittbuhl

Rhythmicity is central to retinal physiology and underlies adaptation of visual function to the changes in light intensity occurring along the 24h day/night cycle.

Rhythmic processes in the retina are controlled by a circadian clock located within the tissue. Our work aims at understanding its molecular and cellular mechanisms, its organization into a network of oscillators and its synchronization with the light/dark cycle. We also study transcriptional regulations downstream of the clock in order to identify mechanisms driving retinal physiology.


Amandine Bery

Marie-Paule Felder-Schmittbuhl

Udita Bagchi

Shumet Gegnaw

Nadia Mazzaro

Nemanja Milicevic

Cristina Sandu


Arthur Bergen, UMC Amsterdam
Ouria Dkhissi-Benyahya, Institut Cellules Souche et Cerveau, Bron
Ségolen Geffray, IRMA, Strasbourg
Chantal Mathis, LNCA, Strasbourg
Anand Swaroop, NEY, NIH, Bethesda, USA
Prapimpun Wongchitrat, Mahidol University, Bangkok, Thailand

Selected publications

Jaeger C, Sandu C, Malan A, Mellac K, Hicks D, Felder-Schmittbuhl MP. Circadian organization of the rodent retina involves strongly coupled, layer-specific oscillators. FASEB J (2015) 29, 1493-1504. doi: 10.1096/fj.14-261214.

Felder-Schmittbuhl MP, Buhr ED, Dkhissi-Benyahya O, Hicks D, Peirson SN, Ribelayga CP, Sandu C, Spessert R, Tosini G. Ocular Clocks: Adapting Mechanisms for Eye Functions and Health. Invest Ophthalmol Vis Sci. (2018) 59:4856-4870. doi: 10.1167/iovs.18-24957.

Calligaro H, Coutanson C, Najjar RP, Mazzaro N, Cooper HM, Haddjeri N, Felder-Schmittbuhl MP, Dkhissi-Benyahya O. Rods contribute to the light-induced phase shift of the retinal clock in mammals.
PLoS Biol (2019) 17:e2006211. doi: 10.1371/journal.pbio.2006211

Milićević N, Mazzaro N, de Bruin I, Wils E, Ten Brink J, Asbroek AT, Mendoza J, Bergen A, Felder-Schmittbuhl MP. Rev-Erbα and Photoreceptor Outer Segments modulate the Circadian Clock in Retinal Pigment Epithelial Cells. Sci Rep (2019) 9:11790. doi: 10.1038/s41598-019-48203-3.


The French National Centre for Scientific Research