Neuroanatomy of brain circuits
Project leader : Pierre VEINANTE
The normal functioning of the brain relies on an extremely complex anatomical organization, in which a multitude of neuronal subtypes establishes specific connections between the different structures. Pathologies such as chronic pain, mood or emotional disorders, are mostly associated with subtle morphofunctional dysfunctions, rather than with large changes in a given structure.
Through multiple morphofunctional approaches in rodents (neuronal tract-tracing, histochemistry, immuno-fluorescence…), we aim at (1) defining the connectomes of the keys structures pertinent for the team’s projects (cingulate cortex, amygdala, tail of the ventral tegmental area, hypothalamus…), (2) identifying the connections contributing to painful and affective symptoms and (3) characterizing, at cellular level, the morphological and neurochemical changes occurring in models of chronic pain and mood disorders.
(Study engineer, IE)
Ye J, Veinante P (2019) Cell-type specific parallel circuits in the bed nucleus of the stria terminalis and the central nucleus of the amygdala of the mouse. Brain Structure & Function 224:1067-1085
Fillinger C, Yalcin I, Barrot M, Veinante P (2018) Efferents of anterior cingulate areas 24a and 24b and midcingulate areas 24a’ and 24b’ in the mouse. Brain Structure & Function 223:1747-1778
Fillinger C, Yalcin, Barrot M, Veinante P (2017) Afferents to anterior cingulate areas 24a and 24b and midcingulate areas 24a’ and 24b’ in the mouse. Brain Structure & Function 222:1509-1532