Synaptic interactions in olfactory bulb circuits
Project leader : Didier DESAINTJAN
Our earlier work focused on intraglomerular excitatory interactions that generate the surprisingly complex and long-lasting synaptic activation of mitral and tufted cells (De Saint Jan and Westbrook, JNeurosci 2007; De Saint Jan et al., JNeurosci 2009; Najac et al., JNeurosci 2011).
Basal forebrain GABAergic axons (red) in the glomerular layer of the olfactory bulb. Calretinin-expressing PG cells (white) delineate three glomeruli.
Currently, our goal is to understand the functional implications of the diverse subtypes of periglomerular interneurons mediating intraglomerular inhibition. Recently, we have described a major circuit and the neuronal subtypes mediating intraglomerular inhibition (Najac et al., JNeurosci 2015). We have also characterized the properties of calretinin-expressing periglomerular cells (Benito et al., bioRxiv 2018) and revealed the connections made by basal forebrain GABAergic axons on diverse subtypes of periglomerular interneurons (Sanz Diez et al., bioRxiv 216259, 2017).
J Physiol. 2019 May;597(9):2547-2563.
A Pool of Postnatally Generated Interneurons Persists in an Immature Stage in the Olfactory Bulb. Benito N, Gaborieau E, Sanz Diez A, Kosar S, Foucault L, Raineteau O, De Saint Jan D.
J Neurosci. 2018 Nov 14;38(46):9870-9882.