The French National Centre for Scientific Research


Sensorimotor information processing in the spinal cord, in normal and pathological conditions


Project leader : Matilde CORDERO-ERAUSQUIN

left, Spinal dorsal horn cholinergic neuron (filled with a tracer through the patch-pipette). Right, Schematic organization of these neurons in the spinal cord.

In the spinal cord takes place the first relay of sensory (and in particular nociceptive) information, as well as the last relay of motor command. Sensory information is integrated at the spinal level and can directly induce a motor response, or be relayed to supraspinal centers where they will contribute to the planification of motor actions.

Our projects aim at elucidating the neuronal circuits responsible for the integration of nociceptive sensory information in the dorsal spinal cord, and more broadly, for the sensorimotor integration at the spinal level. In particular, we are interested in:

* spinal dorsal horn cholinergic interneurons, involved in cholinergic analgesia
* spinal cholinergic premotor V0c neurons, at the interface between sensory and motor pathways
* spinal targets of the corticospinal pathway, involved in sensory or motor control



Members

Matilde Cordero-Erausquin
Matilde Cordero-Erausquin
PhD, HDR

Charlotte Bichara
PhD student

Gilles Delbecq
PhD student

Collaborators

Chris De Zeeuw (NIN, Amsterdam, Nederthlands)
Marie-Eve Paquet (Cervo, Université Laval, Québec, Canada)
Ipek Yalcin (INCI, Université de Strasbourg, France)
Yves De Koninck (Cervo, Université Laval, Québec, Canada)
Alfredo Ribeiro-da-Silva (McGill Univeristy, Montréal, Canada)



Selected publications

Loss of inhibitory tone on spinal cord dorsal horn spontaneously and nonspontaneously active neurons in a mouse model of neuropathic pain. Medrano MC, Dhanasobhon D, Yalcin I, Schlichter R, Cordero-Erausquin M.
Pain. 2016 Jul;157(7):1432-42.

A novel population of cholinergic neurons in the macaque spinal dorsal horn of potential clinical relevance for pain therapy. Pawlowski SA, Gaillard S, Ghorayeb I, Ribeiro-da-Silva A, Schlichter R,
Cordero-Erausquin M.
J Neurosci. 2013 Feb 27;33(9):3727-37.

 


 
The French National Centre for Scientific Research