The French National Centre for Scientific Research


Secretion and neuroendocrine tumors


Project leader : Stéphane Gasman



Neuroendocrine tumours, a heterogeneous group of tumors arising from hormone-secreting cells, are generally associated with a dysfunction of the exocytic pathway leading to hypersecretion. This aspect is well known by the clinicians because hormonal hypersecretion induces severe clinical complications and can favor tumor development. However, the underlying mechanisms have never been explored at the cellular level. The aim of this project is to uncover the molecular and cellular mechanisms responsible for hypersecretion in neuroendocrine tumor using, as experimental model, the human pheochromocytoma, a tumor originating from adrenal medulla chromaffin cells. Uncovering why and how secretion in neuroendocrine tumors becomes uncontrolled will help to develop therapy strategies aiming to prevent hypersecretion of the tumor, hence decreasing the associated-clinical risks.



Members

Stéphane Gasman Stéphane Gasman
(Senior researcher)
 
Stéphane Ory Stéphane Ory
(Researcher)
 
Petra Tóth Petra Tóth
(Associate professor)
 
Nicolas Vitale Nicolas Vitale
(Senior researcher)
 
Laura Streit Laura Streit
(Ph.D. Student)
 
Claudine Boissier Claudine Boissier
 
Anne-Marie Haeberlé Anne-Marie Haeberlé
 
Tamou Thahouly Tamou Thahouly
 

Collaborators

– Laurent Brunaud, PU-PH, Brabois Hospital, CHU NANCY, France.
– Didier Mutter, PU-PH, NHC Hospital, Strasbourg, France.
– FIRALIS company, Huningue, France.
– CAPRION company, Montreal, Canada.



Selected publications

Streit L, Brunaud L, Vitale N, Ory S, Gasman S (2020) Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. Cancers 12(7):1859.

Moog S, Houy S, Chevalier E, Ory S, Weryha G, Rame M, Klein M, Brunaud L, Gasman S, Cuny T (2018) 18F-FDOPA PET/CT Uptake Parameters Correlate with Catecholamine Secretion in Human Pheochromocytomas. Neuroendocrinology 107:228-236.

Croise P, Brunaud L, Toth P, Gasman S, Ory S (2017) Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor. Small GTPases 8:122-127.

Croise P, Houy S, Gand M, Lanoix J, Calco V, Toth P, Brunaud L, Lomazzi S, Paramithiotis E, Chelsky D, Ory S, Gasman S (2016) Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression. Endocr Relat Cancer 23:281-293.

 


 
The French National Centre for Scientific Research